7X5O
Crystal structure of E. faecium SHMT in complex with Me-THF and PLP-Gly
Summary for 7X5O
Entry DOI | 10.2210/pdb7x5o/pdb |
Related | 7V3D 7X5N |
Descriptor | Serine hydroxymethyltransferase, N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ... (4 entities in total) |
Functional Keywords | e. faecium, serine hydroxymethyltransferase, 1c metabolism, transferase |
Biological source | Enterococcus faecium |
Total number of polymer chains | 2 |
Total formula weight | 92000.86 |
Authors | Hasegawa, K.,Hayashi, H. (deposition date: 2022-03-05, release date: 2022-07-06, Last modification date: 2023-11-29) |
Primary citation | Makino, Y.,Oe, C.,Iwama, K.,Suzuki, S.,Nishiyama, A.,Hasegawa, K.,Okuda, H.,Hirata, K.,Ueno, M.,Kawaji, K.,Sasano, M.,Usui, E.,Hosaka, T.,Yabuki, Y.,Shirouzu, M.,Katsumi, M.,Murayama, K.,Hayashi, H.,Kodama, E.N. Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors. Commun Biol, 5:619-619, 2022 Cited by PubMed: 35739195DOI: 10.1038/s42003-022-03555-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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