7X3P

Crystal structure of human SIRT5 in complex with diazirine inhibitor 9

Summary for 7X3P

• Entry DOI: 10.2210/pdb7x3p/pdb
• Descriptor: NAD-dependent protein deacylase sirtuin-5, mitochondrial, 5-[[(5~{S})-6-[[(1~{S})-1-(4-hydroxyphenyl)-2-oxidanylidene-2-(prop-2-ynylamino)ethyl]amino]-6-oxidanylidene-5-[[4-[3-(trifluoromethyl)-1,2-diazirin-3-yl]phenyl]carbonylamino]hexyl]amino]-5-sulfanylidene-pentanoic acid, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 31029.54

Authors

Li, G.-B.,Deng, J. (deposition date: 2022-03-01, release date: 2023-09-06)

• Primary citation: Li, G.-B.,Deng, J.; Crystal structure of human SIRT5 in complex with diazirine inhibitor 9; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.56 Å)