7WVK
Crystal structure of human WDR5 in complex with compound 19
Summary for 7WVK
Entry DOI | 10.2210/pdb7wvk/pdb |
Descriptor | WD repeat-containing protein 5, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... (5 entities in total) |
Functional Keywords | blocker, complex structure, dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35334.83 |
Authors | |
Primary citation | Han, Q.L.,Zhang, X.L.,Ren, P.X.,Mei, L.H.,Lin, W.H.,Wang, L.,Cao, Y.,Li, K.,Bai, F. Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44:877-887, 2023 Cited by PubMed: 36207403DOI: 10.1038/s41401-022-00999-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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