7WKX
IL-17A in complex with the humanized antibody HB0017
Summary for 7WKX
Entry DOI | 10.2210/pdb7wkx/pdb |
Descriptor | Heavy chain of HB0017 Fab, Light chain of HB0017 Fab, Interleukin-17A, ... (6 entities in total) |
Functional Keywords | hb0017, il17a, monoclonal antibody, complex, cytokine |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 130062.77 |
Authors | |
Primary citation | Xu, J.G.,Jia, H.,Chen, S.,Xu, J.,Zhan, Y.,Yu, H.,Wang, W.,Kang, X.,Cui, X.,Feng, Y.,Chen, X.,Xu, W.,Pan, X.,Wei, X.,Li, H.,Wang, Y.,Xia, S.,Liu, X.,Yang, L.,He, Y.,Zhu, X. Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases. Int.J.Biol.Macromol., 202:529-538, 2022 Cited by PubMed: 35066019DOI: 10.1016/j.ijbiomac.2022.01.119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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