7WKI

Structure of the ultra-affinity complex between CFH and a nanobody

Summary for 7WKI

• Entry DOI: 10.2210/pdb7wki/pdb
• Descriptor: Complement factor H, Anti-CFH nanobody (VHH) (3 entities in total)
• Functional Keywords: ultra-high affinity; nanobody; atypical hemolytic uremic syndrome; complement system; autoantibody; autoimmune disease, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 37160.48

Authors

Caaveiro, J.M.M.,Yokoo, T.,Tsumoto, K. (deposition date: 2022-01-10, release date: 2022-11-23, Last modification date: 2023-11-29)

• Primary citation: Yokoo, T.,Tanabe, A.,Yoshida, Y.,Caaveiro, J.M.M.,Nakakido, M.,Ikeda, Y.,Fujimura, Y.,Matsumoto, M.,Entzminger, K.,Maruyama, T.,Okumura, C.J.,Nangaku, M.,Tsumoto, K.; Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis.; J.Biol.Chem., 298:101962-101962, 2022; PubMed: 35452676; DOI: 10.1016/j.jbc.2022.101962

Experimental method

X-RAY DIFFRACTION (2.6 Å)