7WJV

Crystal structure of human liver FBPase complexed with an covalent inhibitor

7WJV の概要

• エントリーDOI: 10.2210/pdb7wjv/pdb
• 分子名称: Fructose-1,6-bisphosphatase 1, ADENOSINE MONOPHOSPHATE, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ... (7 entities in total)
• 機能のキーワード: classification: hydrolase organism(s): homo sapiens expression system: escherichia coli bl21(de3) inhibitor: covalent binding c128, cytosolic protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 154875.51

構造登録者

Cao, H.,Huang, Y.,Ren, Y.,Wan, J. (登録日: 2022-01-08, 公開日: 2022-07-13, 最終更新日: 2023-11-29)

• 主引用文献: Wen, W.,Cao, H.,Xu, Y.,Ren, Y.,Rao, L.,Shao, X.,Chen, H.,Wu, L.,Liu, J.,Su, C.,Peng, C.,Huang, Y.,Wan, J.; N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction.; J.Med.Chem., 65:9126-9143, 2022; PubMed: 35786925; DOI: 10.1021/acs.jmedchem.2c00336

実験手法

X-RAY DIFFRACTION (1.724 Å)