7W6A

Crystal structure of the MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L complex

7W6A の概要

• エントリーDOI: 10.2210/pdb7w6a/pdb
• 分子名称: Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... (6 entities in total)
• 機能のキーワード: mll family methyltransferases, product specificity, f/y switch, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 42616.70

構造登録者

Zhao, L.,Li, Y.,Chen, Y. (登録日: 2021-12-01, 公開日: 2022-09-07, 最終更新日: 2023-11-29)

• 主引用文献: Li, Y.,Zhao, L.,Zhang, Y.,Wu, P.,Xu, Y.,Mencius, J.,Zheng, Y.,Wang, X.,Xu, W.,Huang, N.,Ye, X.,Lei, M.,Shi, P.,Tian, C.,Peng, C.,Li, G.,Liu, Z.,Quan, S.,Chen, Y.; Structural basis for product specificities of MLL family methyltransferases.; Mol.Cell, 82:3810-3825.e8, 2022; PubMed: 36108631; DOI: 10.1016/j.molcel.2022.08.022

実験手法

X-RAY DIFFRACTION (2.21 Å)