7W4A
Cryo-EM structure of the gastric proton pump complexed with revaprazan
Summary for 7W4A
Entry DOI | 10.2210/pdb7w4a/pdb |
EMDB information | 32299 |
Descriptor | Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta, N-(4-fluorophenyl)-4,5-dimethyl-6-[(1R)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]pyrimidin-2-amine, ... (8 entities in total) |
Functional Keywords | cation pump, p-type atpase, gastric, proton pump, membrane protein, p-cab, hydrolase |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 2 |
Total formula weight | 149431.06 |
Authors | Abe, K.,Tanaka, S.,Morita, M.,Yamagishi, T. (deposition date: 2021-11-26, release date: 2022-03-02, Last modification date: 2022-07-20) |
Primary citation | Tanaka, S.,Morita, M.,Yamagishi, T.,Madapally, H.V.,Hayashida, K.,Khandelia, H.,Gerle, C.,Shigematsu, H.,Oshima, A.,Abe, K. Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump. J.Med.Chem., 65:7843-7853, 2022 Cited by PubMed: 35604136DOI: 10.1021/acs.jmedchem.2c00338 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.76 Å) |
Structure validation
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