7VTC

Crystal structure of MERS main protease in complex with PF07321332

Summary for 7VTC

• Entry DOI: 10.2210/pdb7vtc/pdb
• Descriptor: 3C-like proteinase, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
• Functional Keywords: viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Middle East respiratory syndrome-related coronavirus (MERS-CoV)
• Total number of polymer chains: 2
• Total formula weight: 70972.03

Authors

Lin, C.,Zhong, F.L.,Zhou, X.L.,Zhang, J.,Li, J. (deposition date: 2021-10-28, release date: 2022-03-30, Last modification date: 2023-11-29)

• Primary citation: Li, J.,Lin, C.,Zhou, X.,Zhong, F.,Zeng, P.,Yang, Y.,Zhang, Y.,Yu, B.,Fan, X.,McCormick, P.J.,Fu, R.,Fu, Y.,Jiang, H.,Zhang, J.; Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.; J.Virol., 96:e0201321-e0201321, 2022; PubMed: 35389231; DOI: 10.1128/jvi.02013-21

Experimental method

X-RAY DIFFRACTION (2.53865625155 Å)