7VPX

The cryo-EM structure of the human pre-A complex

Summary for 7VPX

• Entry DOI: 10.2210/pdb7vpx/pdb
• EMDB information: 32074 32075 32076
• Descriptor: Splicing factor 3A subunit 2, Splicing factor 3A subunit 1, Splicing factor 3A subunit 3, ... (30 entities in total)
• Functional Keywords: human spliceosome, pre-a complex, prp5, a complex, u1 snrnp, u2 snrnp, splicing
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 35
• Total formula weight: 1405823.07

Authors

Zhang, X.,Zhan, X.,Shi, Y. (deposition date: 2021-10-18, release date: 2023-05-03, Last modification date: 2024-05-22)

• Primary citation: Zhang, X.,Zhan, X.,Bian, T.,Yang, F.,Li, P.,Lu, Y.,Xing, Z.,Fan, R.,Zhang, Q.C.,Shi, Y.; Structural insights into branch site proofreading by human spliceosome.; Nat.Struct.Mol.Biol., 2024; PubMed: 38196034; DOI: 10.1038/s41594-023-01188-0

Experimental method

ELECTRON MICROSCOPY (3 Å)