7VKE
Crystal structure of human CD38 ECD in complex with UniDab(TM) F11A
Summary for 7VKE
Entry DOI | 10.2210/pdb7vke/pdb |
Descriptor | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Unidab F11A, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | complex, transferase, antibody, receptor, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 45610.03 |
Authors | Schooten, W.V.,Schellenberger, U.,Ugamraj, H.S.,Manicka, S.,Bijpuria, S.,Gondu, R.K. (deposition date: 2021-09-29, release date: 2022-08-03, Last modification date: 2023-11-29) |
Primary citation | Ugamraj, H.S.,Dang, K.,Ouisse, L.H.,Buelow, B.,Chini, E.N.,Castello, G.,Allison, J.,Clarke, S.C.,Davison, L.M.,Buelow, R.,Deng, R.,Iyer, S.,Schellenberger, U.,Manika, S.N.,Bijpuria, S.,Musnier, A.,Poupon, A.,Cuturi, M.C.,van Schooten, W.,Dalvi, P. TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity. Mabs, 14:2095949-2095949, 2022 Cited by PubMed: 35867844DOI: 10.1080/19420862.2022.2095949 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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