7VI0
Crystal structure of EP300 HAT domain in complex with compound 11
Summary for 7VI0
Entry DOI | 10.2210/pdb7vi0/pdb |
Descriptor | Histone acetyltransferase p300, ZINC ION, (4S)-N-(3H-indazol-4-yl)-3-[1-(4-methoxyphenyl)cyclopentyl]carbonyl-1,1-bis(oxidanylidene)-1,3-thiazolidine-4-carboxamide, ... (4 entities in total) |
Functional Keywords | epigenetics, sbdd, histone acetyltransferase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 106169.01 |
Authors | Takahashi, M.,Hanzawa, H. (deposition date: 2021-09-24, release date: 2022-04-27, Last modification date: 2023-11-29) |
Primary citation | Kanada, R.,Kagoshima, Y.,Asano, M.,Suzuki, T.,Murata, T.,Haruta, M.,Takahashi, M.,Ubukata, O.,Hashimoto, K.,Obata, K.,Kihara, K.,Kuroha, M.,Banjo, T.,Togashi, N.,Sato, K.,Yamamoto, Y.,Suzuki, K.,Isoyama, T.,Tominaga, Y.,Higuchi, S.,Naito, H. Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg.Med.Chem.Lett., 66:128726-128726, 2022 Cited by PubMed: 35413416DOI: 10.1016/j.bmcl.2022.128726 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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