7VDU
The structure of cyclin-dependent kinase 2 (CDK2) in complex with Compound 1
Summary for 7VDU
Entry DOI | 10.2210/pdb7vdu/pdb |
Descriptor | Cyclin-dependent kinase 2, [1-[3-fluoranyl-4-[(2-piperidin-4-yloxy-1,6-naphthyridin-7-yl)amino]phenyl]pyrazol-3-yl]methanol (3 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34582.09 |
Authors | Malojcic, G.,Clugston, S.L.,Daniels, M.,Harmange, J.C.,Ledeborer, M. (deposition date: 2021-09-07, release date: 2022-03-09, Last modification date: 2023-11-29) |
Primary citation | Daniels, M.H.,Malojcic, G.,Clugston, S.L.,Williams, B.,Coeffet-Le Gal, M.,Pan-Zhou, X.R.,Venkatachalan, S.,Harmange, J.C.,Ledeboer, M. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J.Med.Chem., 65:3575-3596, 2022 Cited by PubMed: 35143203DOI: 10.1021/acs.jmedchem.1c02069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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