7V4G

Crystal structure of human ALKBH5 in complex with m6A-containing ssRNA

7V4G の概要

• エントリーDOI: 10.2210/pdb7v4g/pdb
• 分子名称: RNA (5'-R(P*GP*GP*(6MZ)P*C)-3'), RNA demethylase ALKBH5, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: iron and 2-oxoglutarate dependent oxygenase, rna demethylase, double-stranded beta helix, oxidoreductase-rna complex, oxidoreductase/rna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 83907.60

構造登録者

Kaur, S.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. (登録日: 2021-08-13, 公開日: 2022-03-30, 最終更新日: 2023-11-29)

• 主引用文献: Kaur, S.,Tam, N.Y.,McDonough, M.A.,Schofield, C.J.,Aik, W.S.; Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.; Nucleic Acids Res., 50:4148-4160, 2022; PubMed: 35333330; DOI: 10.1093/nar/gkac195

実験手法

X-RAY DIFFRACTION (2.1 Å)