7UUO

Crystal structure of aminoglycoside resistance enzyme ApmA H135A mutant, complex with tobramycin and coenzyme A

7UUO の概要

• エントリーDOI: 10.2210/pdb7uuo/pdb
• 関連するPDBエントリー: 7UUJ 7UUK 7UUL 7UUM 7UUN
• 分子名称: Aminocyclitol acetyltransferase ApmA, TOBRAMYCIN, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: xat, xenobiotic acetyltransferase, left-handed beta helix, lbh, antibiotic resistance, aminoglycoside, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 96003.91

構造登録者

Stogios, P.J.,Evdokimova, E.,Michalska, K.,Di Leo, R.,Bordeleau, E.,Wright, G.D.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID),Center for Structural Biology of Infectious Diseases (CSBID) (登録日: 2022-04-28, 公開日: 2022-11-02, 最終更新日: 2024-02-14)

• 主引用文献: Bordeleau, E.,Stogios, P.J.,Evdokimova, E.,Koteva, K.,Savchenko, A.,Wright, G.D.; Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.; Nat.Chem.Biol., 20:234-242, 2024; PubMed: 37973888; DOI: 10.1038/s41589-023-01483-3

実験手法

X-RAY DIFFRACTION (2.65 Å)