7UUJ

Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin

Summary for 7UUJ

• Entry DOI: 10.2210/pdb7uuj/pdb
• Related: 7UUK 7UUL 7UUM 7UUN 7UUO
• Descriptor: Aminocyclitol acetyltransferase ApmA, (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: xat, xenobiotic acetyltransferase, left-handed beta helix, lbh, antibiotic resistance, aminoglycoside, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase, center for structural biology of infectious diseases, csbid
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 3
• Total formula weight: 95653.92

Authors

Stogios, P.J.,Evdokimova, E.,Osipiuk, J.,Di Leo, R.,Bordeleau, E.,Wright, G.D.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2022-04-28, release date: 2023-04-19, Last modification date: 2023-10-25)

• Primary citation: Stogios, P.J.; Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.78 Å)