7USZ

Human DDAH-1, holo (Zn-bound) form

Summary for 7USZ

• Entry DOI: 10.2210/pdb7usz/pdb
• Descriptor: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, ZINC ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: cardiovascular enzyme, proton pump inhibitors, esomeprazole, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 63055.81

Authors

Smith, C.A.,Ghebre, Y.T. (deposition date: 2022-04-26, release date: 2022-05-11, Last modification date: 2023-10-18)

• Primary citation: Smith, C.A.,Ebrahimpour, A.,Novikova, L.,Farina, D.,Bailey, A.O.,Russell, W.K.,Jain, A.,Saltzman, A.B.,Malovannaya, A.,Prasad, B.V.V.,Hu, L.,Ghebre, Y.T.; Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors.; Biochim Biophys Acta Gen Subj, 1866:130149-130149, 2022; PubMed: 35472493; DOI: 10.1016/j.bbagen.2022.130149

Experimental method

X-RAY DIFFRACTION (1.65 Å)