7UQ3
JmjC domain-containing protein 5 (JMJD5) in complex with Mn and (S)-2-(1-hydroxy-2,5-dioxopyrrolidin-3-yl)acetic acid
Summary for 7UQ3
| Entry DOI | 10.2210/pdb7uq3/pdb |
| Descriptor | Bifunctional peptidase and arginyl-hydroxylase JMJD5, MANGANESE (II) ION, [(3S)-1-hydroxy-2,5-dioxopyrrolidin-3-yl]acetic acid, ... (5 entities in total) |
| Functional Keywords | oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, jmjc, jmjc domain, lysine-specific demethylase 8, jmjc domain-containing protein 5, arginyl c-3 hydroxylase, jmjd5, kdm8, oxygenase, hypoxia, dna-binding, metal-binding, translation, dsbh, facial triad, cytoplasm, jmjc hydroxylase, jmjc demethylase, kdms, post-translational modifications, ptm, beta-hydroxylation, hydroxylation, arginine hydroxylation, rcc1 domain-containing protein 1, rccd1, regulator of chromosome condensation, 40s ribosomal protein s6, rps6, ribosome biogenesis, transcription, epigenetic regulation, signaling, development, cell structure, transcription activator/inhibitor, phosphorylation, cancer, polymorphism |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 30145.80 |
| Authors | Chowdhury, R.,Islam, M.S.,Schofield, C.J. (deposition date: 2022-04-19, release date: 2022-12-21, Last modification date: 2023-10-25) |
| Primary citation | Islam, M.S.,Markoulides, M.,Chowdhury, R.,Schofield, C.J. Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5. Sci Rep, 12:20680-20680, 2022 Cited by PubMed: 36450832DOI: 10.1038/s41598-022-24154-0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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