7UOV

Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D

7UOV の概要

• エントリーDOI: 10.2210/pdb7uov/pdb
• 関連するPDBエントリー: 7UOT
• EMDBエントリー: 26653 26655
• 分子名称: 12.1F heavy chain (variable domain), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• 機能のキーワード: lassa virus, neutralizing antibody, n-linked glycans complex, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 340329.13

構造登録者

Li, H.,Saphire, E.O. (登録日: 2022-04-14, 公開日: 2022-11-02)

• 主引用文献: Li, H.,Buck, T.,Zandonatti, M.,Yin, J.,Moon-Walker, A.,Fang, J.,Koval, A.,Heinrich, M.L.,Rowland, M.M.,Diaz Avalos, R.,Schendel, S.L.,Parekh, D.,Zyla, D.,Enriquez, A.,Harkins, S.,Sullivan, B.,Smith, V.,Chukwudozie, O.,Watanabe, R.,Robinson, J.E.,Garry, R.F.,Branco, L.M.,Hastie, K.M.,Saphire, E.O.; A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus.; Sci Transl Med, 14:eabq0991-eabq0991, 2022; PubMed: 36288283; DOI: 10.1126/scitranslmed.abq0991

実験手法

ELECTRON MICROSCOPY (2.75 Å)