7UL1

Crystal structure of SARS-CoV-2 RBD in complex with the neutralizing IGHV3-53-encoded antibody EH3 isolated from a nonvaccinated pediatric patient

7UL1 の概要

• エントリーDOI: 10.2210/pdb7ul1/pdb
• 関連するPDBエントリー: 7UL0
• 分子名称: Spike protein S1, Heavy chain of EH3, Light chain of EH3, ... (5 entities in total)
• 機能のキーワード: pediatric neutralizing mab, ighv3-53 ab, , class-1 rbd-binding antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70377.66

構造登録者

Chen, Y.,Tolbert, W.D.,Pazgier, M. (登録日: 2022-04-03, 公開日: 2023-03-08, 最終更新日: 2023-10-25)

• 主引用文献: Chen, Y.,Prevost, J.,Ullah, I.,Romero, H.,Lisi, V.,Tolbert, W.D.,Grover, J.R.,Ding, S.,Gong, S.Y.,Beaudoin-Bussieres, G.,Gasser, R.,Benlarbi, M.,Vezina, D.,Anand, S.P.,Chatterjee, D.,Goyette, G.,Grunst, M.W.,Yang, Z.,Bo, Y.,Zhou, F.,Beland, K.,Bai, X.,Zeher, A.R.,Huang, R.K.,Nguyen, D.N.,Sherburn, R.,Wu, D.,Piszczek, G.,Pare, B.,Matthies, D.,Xia, D.,Richard, J.,Kumar, P.,Mothes, W.,Cote, M.,Uchil, P.D.,Lavallee, V.P.,Smith, M.A.,Pazgier, M.,Haddad, E.,Finzi, A.; Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.; Iscience, 26:105783-105783, 2023; PubMed: 36514310; DOI: 10.1016/j.isci.2022.105783

実験手法

X-RAY DIFFRACTION (2.65 Å)