7UDP

Crystal structure of COQ8A-CA157 inhibitor complex in space group C2

Summary for 7UDP

Entry DOI	10.2210/pdb7udp/pdb
Descriptor	Atypical kinase COQ8A, mitochondrial, 4-[(3,4,5-trimethoxyphenyl)amino]quinoline-7-carbonitrile (3 entities in total)
Functional Keywords	coq biosynthesis, kinase-like, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	45583.32
Authors	Bingman, C.A.,Murray, N.,Smith, R.W.,Pagliarini, D.J. (deposition date: 2022-03-20, release date: 2023-01-18, Last modification date: 2023-10-25)
Primary citation	Murray, N.H.,Asquith, C.R.M.,Fang, Z.,East, M.P.,Ptak, N.,Smith, R.W.,Vasta, J.D.,Zimprich, C.A.,Corona, C.R.,Robers, M.B.,Johnson, G.L.,Bingman, C.A.,Pagliarini, D.J. Small-molecule inhibition of the archetypal UbiB protein COQ8. Nat.Chem.Biol., 19:230-238, 2023 Cited by PubMed: 36302899 DOI: 10.1038/s41589-022-01168-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation