7UD6

Designed Enzyme SH3-588 (Catechol O-methyltransferase catalytic domain and Src homology 3 binding domain fusion)

7UD6 の概要

• エントリーDOI: 10.2210/pdb7ud6/pdb
• 分子名称: Tyrosine-protein kinase Fyn,Catechol O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, POTASSIUM ION, ... (4 entities in total)
• 機能のキーワード: designed enzyme, comt, sh3, fusion protein, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33057.52

構造登録者

Ongpipattanakul, C.,Nair, S.K. (登録日: 2022-03-18, 公開日: 2023-01-11, 最終更新日: 2023-10-25)

• 主引用文献: Park, R.,Ongpipattanakul, C.,Nair, S.K.,Bowers, A.A.,Kuhlman, B.; Designer installation of a substrate recruitment domain to tailor enzyme specificity.; Nat.Chem.Biol., 19:460-467, 2023; PubMed: 36509904; DOI: 10.1038/s41589-022-01206-0

実験手法

X-RAY DIFFRACTION (2.59 Å)