7U9I
Co-crystal structure of human CARM1 in complex with MT556 inhibitor
Summary for 7U9I
Entry DOI | 10.2210/pdb7u9i/pdb |
Descriptor | Histone-arginine methyltransferase CARM1, 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, UNKNOWN ATOM OR ION, ... (4 entities in total) |
Functional Keywords | mtase, histone arginine methyltransferase, prmt4, carm1, sgc, structural genomics, structural genomics consortium, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 79012.21 |
Authors | Zeng, H.,Perveen, S.,Dong, A.,Hutchinson, A.,Seitova, A.,Gibson, E.,Hajian, T.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2022-03-10, release date: 2023-01-18, Last modification date: 2023-10-25) |
Primary citation | Zeng, H.,Perveen, S.,Dong, A.,Hutchinson, A.,Seitova, A.,Gibson, E.,Hajian, T.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) Co-crystal structure of human CARM1 in complex with MT556 inhibitor To Be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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