7U9I
Co-crystal structure of human CARM1 in complex with MT556 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-arginine methyltransferase CARM1 | polymer | 345 | 39033.5 | 2 | UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528) | Homo sapiens (human) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | C, G (A, B) | 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | non-polymer | 472.6 | 2 | Chemie (44T) PubChem (156026036) | |||
| 3 | D, E, F, H, I... (A, B) | UNKNOWN ATOM OR ION | non-polymer | 14 | Chemie (UNX) | ||||
| 4 | S, T (A, B) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A, B: 146 - 489 (UniProt: Q86X55)
| PDB | External Database | Details |
|---|---|---|
| Gly 145 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78067.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 945.2 | |
| All* | Total formula weight | 79012.2 |
