7U8Y
TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics
Summary for 7U8Y
Entry DOI | 10.2210/pdb7u8y/pdb |
Descriptor | Three-prime repair exonuclease 1, ALIZARIN RED, MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | inhibitor, exonuclease, immunotherapy, complex, dna binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 2 |
Total formula weight | 51678.12 |
Authors | Hemphill, W.O.,Harvey, S.E.,Simpson, S.R.,Smalley, T.L.,Salsbury, F.R.,Perrino, F.W.,Hollis, T. (deposition date: 2022-03-09, release date: 2023-03-15, Last modification date: 2023-10-25) |
Primary citation | Hemphill, W.O.,Harvey, S.E.,Simpson, S.R.,Smalley, T.L.,Salsbury, F.R.,Perrino, F.W.,Hollis, T. TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics to be published, |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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