7U6E
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
Summary for 7U6E
Entry DOI | 10.2210/pdb7u6e/pdb |
EMDB information | 26363 26364 |
Descriptor | Insulin A chain, Insulin B chain, Isoform Short of Insulin receptor, ... (6 entities in total) |
Functional Keywords | insulin receptor, insulin-mimic peptide, insulin receptor agonist, hormone-signaling protein-agonist complex, hormone/signaling protein/agonist |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 226315.45 |
Authors | |
Primary citation | Kirk, N.S.,Chen, Q.,Wu, Y.G.,Asante, A.L.,Hu, H.,Espinosa, J.F.,Martinez-Olid, F.,Margetts, M.B.,Mohammed, F.A.,Kiselyov, V.V.,Barrett, D.G.,Lawrence, M.C. Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13:5695-, 2022 Cited by PubMed: 36171189DOI: 10.1038/s41467-022-33315-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
Download full validation report