7U62

Crystal structure of Anti-Heroin Antibody HY4-1F9 Fab Complexed with Morphine

Summary for 7U62

Entry DOI	10.2210/pdb7u62/pdb
Descriptor	HY4-1F9 Fab Heavy Chain, HY4-1F9 Fab Light Chain, (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL, ... (5 entities in total)
Functional Keywords	mab, opioid, immune system
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	4
Total formula weight	95705.96
Authors	Rodarte, J.V.,Pancera, M.P. (deposition date: 2022-03-03, release date: 2023-01-11, Last modification date: 2023-10-25)
Primary citation	Rodarte, J.V.,Baehr, C.,Hicks, D.,Liban, T.L.,Weidle, C.,Rupert, P.B.,Jahan, R.,Wall, A.,McGuire, A.T.,Strong, R.K.,Runyon, S.,Pravetoni, M.,Pancera, M. Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding. Structure, 31:20-32.e5, 2023 Cited by PubMed: 36513069 DOI: 10.1016/j.str.2022.11.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation