7U20

Crystal structure of human METTL1 and WDR4 complex

Summary for 7U20

Entry DOI	10.2210/pdb7u20/pdb
Descriptor	tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, SULFATE ION, ... (4 entities in total)
Functional Keywords	mettl1 wdr4 trna methyltransferase, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	79167.72
Authors	Li, J.,Nowak, R.P.,Fischer, E.S.,Gregory, R. (deposition date: 2022-02-22, release date: 2022-12-07, Last modification date: 2023-10-25)
Primary citation	Li, J.,Wang, L.,Hahn, Q.,Nowak, R.P.,Viennet, T.,Orellana, E.A.,Roy Burman, S.S.,Yue, H.,Hunkeler, M.,Fontana, P.,Wu, H.,Arthanari, H.,Fischer, E.S.,Gregory, R.I. Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature, 613:391-397, 2023 Cited by PubMed: 36599985 DOI: 10.1038/s41586-022-05566-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation