7TYD

Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder in P21 space group

Summary for 7TYD

Entry DOI	10.2210/pdb7tyd/pdb
Related	7N1J
Descriptor	Fibroblast growth factor receptor 4, Binder (3 entities in total)
Functional Keywords	receptor tyrosine kinase, complex, binder, membrane protein, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	43615.39
Authors	Park, J.S.,Lee, S. (deposition date: 2022-02-12, release date: 2022-11-09, Last modification date: 2023-10-18)
Primary citation	Park, J.S.,Choi, J.,Cao, L.,Mohanty, J.,Suzuki, Y.,Park, A.,Baker, D.,Schlessinger, J.,Lee, S. Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein. Cell Rep, 41:111545-111545, 2022 Cited by PubMed: 36288716 DOI: 10.1016/j.celrep.2022.111545 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.86 Å)

Structure validation