7TYD

Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder in P21 space group

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Fibroblast growth factor receptor 4	polymer	132	14271.9	2	UniProt (P22455) Pfam (PF13927)	Homo sapiens (human)	FGFR-4
2	B, D (B, D)	Binder	polymer	64	7535.8	2		synthetic construct
3	E, F (A, C)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

A, C: 245 - 355 (UniProt: P22455)

PDB	External Database	Details
Met 224	-	initiating methionine
Gly 225	-	expression tag
Ser 226	-	expression tag
Ser 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag
His 232	-	expression tag
His 233	-	expression tag
Ser 234	-	expression tag
Ser 235	-	expression tag
Gly 236	-	expression tag
Leu 237	-	expression tag
Val 238	-	expression tag
Pro 239	-	expression tag
Arg 240	-	expression tag
Gly 241	-	expression tag
Ser 242	-	expression tag
His 243	-	expression tag
Met 244	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	43615.4
All*	Total formula weight	43615.4

*Water molecules are not included.