7TXT

Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl

7TXT の概要

• エントリーDOI: 10.2210/pdb7txt/pdb
• EMDBエントリー: 26160
• 分子名称: 15B8 Fab heavy chain, 15B8 Fab light chain, Sodium-dependent serotonin transporter, ... (4 entities in total)
• 機能のキーワード: neurotransmitter transporter, small molecule, membrane protein, transport protein
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 86397.45

構造登録者

Singh, I.,Seth, A.,Billesboelle, C.B.,Braz, J.,Rodriguiz, R.M.,Roy, K.,Bekele, B.,Craik, V.,Huang, X.P.,Boytsov, D.,Lak, P.,O'Donnell, H.,Sandtner, W.,Roth, B.L.,Basbaum, A.I.,Wetsel, W.C.,Manglik, A.,Shoichet, B.K.,Rudnick, G. (登録日: 2022-02-09, 公開日: 2023-03-15, 最終更新日: 2024-03-27)

• 主引用文献: Singh, I.,Seth, A.,Billesbolle, C.B.,Braz, J.,Rodriguiz, R.M.,Roy, K.,Bekele, B.,Craik, V.,Huang, X.P.,Boytsov, D.,Pogorelov, V.M.,Lak, P.,O'Donnell, H.,Sandtner, W.,Irwin, J.J.,Roth, B.L.,Basbaum, A.I.,Wetsel, W.C.,Manglik, A.,Shoichet, B.K.,Rudnick, G.; Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.; Cell, 186:2160-2175.e17, 2023; PubMed: 37137306; DOI: 10.1016/j.cell.2023.04.010

実験手法

ELECTRON MICROSCOPY (3 Å)