7TXC

HIC2 zinc finger domain in complex with the DNA binding motif-2 of the BCL11A enhancer

Summary for 7TXC

• Entry DOI: 10.2210/pdb7txc/pdb
• Descriptor: DNA (5'-D(*AP*GP*AP*TP*AP*AP*TP*GP*CP*CP*AP*AP*CP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*GP*TP*TP*GP*GP*CP*AP*TP*TP*AP*TP*CP*T)-3'), Hypermethylated in cancer 2 protein, ... (4 entities in total)
• Functional Keywords: zinc-finger domain, gene expression, dna binding protein-dna complex, dna binding protein, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 23803.74

Authors

Horton, J.R.,Ren, R.,Cheng, X. (deposition date: 2022-02-08, release date: 2022-06-01, Last modification date: 2022-09-28)

• Primary citation: Huang, P.,Peslak, S.A.,Ren, R.,Khandros, E.,Qin, K.,Keller, C.A.,Giardine, B.,Bell, H.W.,Lan, X.,Sharma, M.,Horton, J.R.,Abdulmalik, O.,Chou, S.T.,Shi, J.,Crossley, M.,Hardison, R.C.,Cheng, X.,Blobel, G.A.; HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription.; Nat.Genet., 54:1417-1426, 2022; PubMed: 35941187; DOI: 10.1038/s41588-022-01152-6

Experimental method

X-RAY DIFFRACTION (3.04 Å)