7TX2
Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-(((5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(4-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)butyl)amino)butanoic acid
Summary for 7TX2
Entry DOI | 10.2210/pdb7tx2/pdb |
Descriptor | Phenylethanolamine N-methyltransferase, 1,2-ETHANEDIOL, 5'-([(3S)-3-amino-3-carboxypropyl]{4-[(4R)-7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl]butyl}amino)-5'-deoxyadenosine, ... (4 entities in total) |
Functional Keywords | transition state analogue, chemical synthesis, drug design, structural biology, neurodegenerative disease, pnmt, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 66088.44 |
Authors | Harijan, R.K.,Mahmoodi, N.,Minnow, Y.V.T.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2022-02-07, release date: 2023-02-15, Last modification date: 2023-10-25) |
Primary citation | Mahmoodi, N.,Minnow, Y.V.T.,Harijan, R.K.,Bedard, G.T.,Schramm, V.L. Cell-Effective Transition-State Analogue of Phenylethanolamine N -Methyltransferase. Biochemistry, 62:2257-2268, 2023 Cited by PubMed: 37467463DOI: 10.1021/acs.biochem.3c00103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
Download full validation report