7TX2
Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-(((5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(4-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)butyl)amino)butanoic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Phenylethanolamine N-methyltransferase | polymer | 294 | 32327.6 | 2 | UniProt (P11086) Pfam (PF01234) In PDB | Homo sapiens (human) | PNMTase,Noradrenaline N-methyltransferase |
2 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
3 | A, B | 5'-([(3S)-3-amino-3-carboxypropyl]{4-[(4R)-7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl]butyl}amino)-5'-deoxyadenosine | non-polymer | 623.5 | 2 | Chemie (KNX) | |||
4 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 282 (UniProt: P11086)
PDB | External Database | Details |
---|---|---|
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
Leu -5 | - | expression tag |
Val -4 | - | expression tag |
Pro -3 | - | expression tag |
Arg -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 64655.2 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1433.3 | |
All* | Total formula weight | 66088.4 |