7TVA

Stat5a Core in complex with AK2292

7TVA の概要

• エントリーDOI: 10.2210/pdb7tva/pdb
• 分子名称: Signal transducer and activator of transcription 5A, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N-(5-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}pent-4-yn-1-yl)-N-methyl-N~3~-[4-(1,3-thiazol-2-yl)phenyl]-beta-alaninamide, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: stat5a, activator, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 134112.01

構造登録者

Meagher, J.L.,Stuckey, J.A. (登録日: 2022-02-04, 公開日: 2023-02-15, 最終更新日: 2024-04-03)

• 主引用文献: Kaneshige, A.,Bai, L.,Wang, M.,McEachern, D.,Meagher, J.L.,Xu, R.,Wang, Y.,Jiang, W.,Metwally, H.,Kirchhoff, P.D.,Zhao, L.,Jiang, H.,Wang, M.,Wen, B.,Sun, D.,Stuckey, J.A.,Wang, S.; A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.; Nat.Chem.Biol., 19:703-711, 2023; PubMed: 36732620; DOI: 10.1038/s41589-022-01248-4

実験手法

X-RAY DIFFRACTION (2.835 Å)