7TO5

HIV-1 wild type protease with GRL-05816A, with C-4 substituted cyclohexane-fused bis-tetrahydrofuran (Chf-THF) derivatives as P2-ligand [diastereomer 1]

Summary for 7TO5

Entry DOI	10.2210/pdb7to5/pdb
Related	2IEN 6BZ2 6VOD 6VOE 7TO6
Descriptor	Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	aspartic acid protease, hiv-1 protease, inhibitors, antiviral protein, antiviral protein-inhibitor complex, antiviral protein/inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22419.66
Authors	Wang, Y.-F.,Agniswamy, J.,Ghosh, A.K.,Weber, I.T. (deposition date: 2022-01-23, release date: 2022-03-02, Last modification date: 2023-10-18)
Primary citation	Ghosh, A.K.,Kovela, S.,Sharma, A.,Shahabi, D.,Ghosh, A.K.,Hopkins, D.R.,Yadav, M.,Johnson, M.E.,Agniswamy, J.,Wang, Y.F.,Hattori, S.I.,Higashi-Kuwata, N.,Aoki, M.,Amano, M.,Weber, I.T.,Mitsuya, H. Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands. Chemmedchem, 17:e202200058-e202200058, 2022 Cited by PubMed: 35170223 DOI: 10.1002/cmdc.202200058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.13 Å)

Structure validation