7TNH

Crystal structure of CSF1R kinase domain in complex with DP-6233

Summary for 7TNH

Entry DOI	10.2210/pdb7tnh/pdb
Descriptor	Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	human csr1r kinase, cancer, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	39083.07
Authors	Edwards, T.E.,Arakaki, T.L.,Chun, L.,Flynn, D.L. (deposition date: 2022-01-21, release date: 2022-08-24, Last modification date: 2023-10-18)
Primary citation	Caldwell, T.M.,Kaufman, M.D.,Wise, S.C.,Mi Ahn, Y.,Hood, M.M.,Lu, W.P.,Patt, W.C.,Samarakoon, T.,Vogeti, L.,Vogeti, S.,Yates, K.M.,Bulfer, S.L.,Le Bourdonnec, B.,Smith, B.D.,Flynn, D.L. Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors. Bioorg.Med.Chem.Lett., 74:128929-128929, 2022 Cited by PubMed: 35961461 DOI: 10.1016/j.bmcl.2022.128929 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation