7TNH

Crystal structure of CSF1R kinase domain in complex with DP-6233

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera	polymer	338	38509.8	1	UniProt (P07333) UniProt (P11362) Pfam (PF07714) In PDB	Homo sapiens (human)	CSF-1 receptor,CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
3	A	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
4	A	2,2-dimethyl-N-[(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide	non-polymer		408.5	1	Chemie (I9W)
5		water	water		18.0	9	Chemie (HOH)

Sequence modifications

A: 549 - 678 (UniProt: P07333)

PDB	External Database	Details
Met 532	-	initiating methionine
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag
Glu 541	-	expression tag
Asn 542	-	expression tag
Leu 543	-	expression tag
Tyr 544	-	expression tag
Phe 545	-	expression tag
Gln 546	-	expression tag
Gly 547	-	expression tag
Ser 548	-	expression tag

A: 679 - 699 (UniProt: P11362)

PDB	External Database	Details
Ser 686	Cys 584	conflict

A: 753 - 922 (UniProt: P07333)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38509.8
Non-Polymers*	Number of molecules	6
	Total formula weight	573.3
All*	Total formula weight	39083.1

*Water molecules are not included.