7TLK
Crystal Structure of K-Ras(G12S)
Summary for 7TLK
Entry DOI | 10.2210/pdb7tlk/pdb |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | ras, oncoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 39538.58 |
Authors | Ziyang, Z.,Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-01-18, release date: 2022-08-03, Last modification date: 2023-10-18) |
Primary citation | Zhang, Z.,Guiley, K.Z.,Shokat, K.M. Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18:1177-1183, 2022 Cited by PubMed: 35864332DOI: 10.1038/s41589-022-01065-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71102224586 Å) |
Structure validation
Download full validation report