7TL8

1.95A resolution structure of independent phosphoglycerate mutase from S. aureus in complex with a macrocyclic peptide inhibitor (Sa-D3)

Summary for 7TL8

Entry DOI	10.2210/pdb7tl8/pdb
Related PRD ID	PRD_002492
Descriptor	2,3-bisphosphoglycerate-independent phosphoglycerate mutase, Peptide Sa-D3, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	phosphoglycerate mutase, ipglycermide, macrocyclic peptide inhibitors, metal ion binding, isomerase, isomerase-inhibitor complex, isomerase/inhibitor
Biological source	Staphylococcus aureus More
Total number of polymer chains	2
Total formula weight	59236.56
Authors	Liu, L.,Lovell, S.,Battaile, K.P.,Dranchak, P.,Queme, B.,Aitha, M.,van Neer, R.H.P.,Kimura, H.,Katho, T.,Suga, H.,Inglese, J. (deposition date: 2022-01-18, release date: 2022-08-10, Last modification date: 2023-10-18)
Primary citation	van Neer, R.H.P.,Dranchak, P.K.,Liu, L.,Aitha, M.,Queme, B.,Kimura, H.,Katoh, T.,Battaile, K.P.,Lovell, S.,Inglese, J.,Suga, H. Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases. Acs Chem.Biol., 17:2284-2295, 2022 Cited by PubMed: 35904259 DOI: 10.1021/acschembio.2c00403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation