7TE7

Estrogen Receptor Alpha Ligand Binding Domain in Complex with RAD1901

7TE7 の概要

• エントリーDOI: 10.2210/pdb7te7/pdb
• 分子名称: Estrogen receptor, (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol (3 entities in total)
• 機能のキーワード: estrogen receptor, breast cancer, hormone therapy, alpha helical bundle, transcription factor, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28813.84

構造登録者

Joiner, C.,Hancock, G.,Young, K.,Hosfield, D.J.,Greene, G.L.,Fanning, S.W. (登録日: 2022-01-04, 公開日: 2022-01-19, 最終更新日: 2023-10-25)

• 主引用文献: Hancock, G.R.,Young, K.S.,Hosfield, D.J.,Joiner, C.,Sullivan, E.A.,Yildiz, Y.,Laine, M.,Greene, G.L.,Fanning, S.W.; Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells.; NPJ Breast Cancer, 8:130-130, 2022; PubMed: 36517522; DOI: 10.1038/s41523-022-00497-9

実験手法

X-RAY DIFFRACTION (1.85 Å)