7TAP

Cryo-EM structure of archazolid A bound to yeast VO V-ATPase

Summary for 7TAP

Entry DOI	10.2210/pdb7tap/pdb
Related	7TAO
EMDB information	25779 25780
Descriptor	V-type proton ATPase subunit c', V-type proton ATPase subunit c'', V0 assembly protein 1, ... (9 entities in total)
Functional Keywords	inhibitor, complex, proton pump, atpase, membrane protein
Biological source	Saccharomyces cerevisiae (baker's yeast) More
Total number of polymer chains	15
Total formula weight	359328.99
Authors	Keon, K.A.,Rubinstein, J.L.,Benlekbir, S.,Kirsch, S.H.,Muller, R. (deposition date: 2021-12-21, release date: 2022-02-23, Last modification date: 2022-03-30)
Primary citation	Keon, K.A.,Benlekbir, S.,Kirsch, S.H.,Muller, R.,Rubinstein, J.L. Cryo-EM of the Yeast V O Complex Reveals Distinct Binding Sites for Macrolide V-ATPase Inhibitors. Acs Chem.Biol., 17:619-628, 2022 Cited by PubMed: 35148071 DOI: 10.1021/acschembio.1c00894 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.8 Å)

Structure validation