7TA6

Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1

Summary for 7TA6

Entry DOI	10.2210/pdb7ta6/pdb
Descriptor	Tumor necrosis factor, Alpha/Beta-peptide-1, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	tumor necrosis factor-alpha, signaling, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	16
Total formula weight	166676.45
Authors	Niu, J.,Bingman, C.A.,Gellman, S.H. (deposition date: 2021-12-20, release date: 2022-06-29, Last modification date: 2024-04-03)
Primary citation	Niu, J.,Cederstrand, A.J.,Eddinger, G.A.,Yin, B.,Checco, J.W.,Bingman, C.A.,Outlaw, V.K.,Gellman, S.H. Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling. J.Am.Chem.Soc., 144:9610-9617, 2022 Cited by PubMed: 35613436 DOI: 10.1021/jacs.1c13717 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation