7T6C

E. coli dihydroorotate dehydrogenase bound to the ubiquinone surrogate DCIP

7T6C の概要

• エントリーDOI: 10.2210/pdb7t6c/pdb
• 関連するPDBエントリー: 7T5K 7T5Y 7T6H
• 分子名称: Dihydroorotate dehydrogenase (quinone), 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, OROTIC ACID, ... (7 entities in total)
• 機能のキーワード: inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82782.15

構造登録者

Horwitz, S.M.,Ambarian, J.A.,Davis, K.M. (登録日: 2021-12-13, 公開日: 2022-03-02, 最終更新日: 2023-10-18)

主引用文献

Horwitz, S.M.,Blue, T.C.,Ambarian, J.A.,Hoshino, S.,Seyedsayamdost, M.R.,Davis, K.M.
Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines.
Rsc Chem Biol, 3:420-425, 2022

PubMed Abstract: Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies.

PubMed: 35441142
DOI: 10.1039/d1cb00255d

実験手法

X-RAY DIFFRACTION (2.53 Å)