7T5Y

E. coli dihydroorotate dehydrogenase bound to the inhibitor HMNQ

7T5Y の概要

• エントリーDOI: 10.2210/pdb7t5y/pdb
• 関連するPDBエントリー: 7T5K 7T6C 7T6H
• 分子名称: Dihydroorotate dehydrogenase (quinone), 3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82457.18

構造登録者

Horwitz, S.M.,Ambarian, J.A.,Davis, K.M. (登録日: 2021-12-13, 公開日: 2022-03-02, 最終更新日: 2023-10-18)

• 主引用文献: Horwitz, S.M.,Blue, T.C.,Ambarian, J.A.,Hoshino, S.,Seyedsayamdost, M.R.,Davis, K.M.; Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines.; Rsc Chem Biol, 3:420-425, 2022; PubMed: 35441142; DOI: 10.1039/d1cb00255d

実験手法

X-RAY DIFFRACTION (2.62 Å)