7T4W
Crystal Structure of cGMP-dependent Protein Kinase
Summary for 7T4W
Entry DOI | 10.2210/pdb7t4w/pdb |
Descriptor | cGMP-dependent protein kinase 1, (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | cyclic nucleotide binding domains, cyclic nucleotide protein kinase, transferase, pkg, cgmp-dependent protein kinase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 107417.97 |
Authors | Zebisch, M.,Silvestre, L.,Fischmann, T.O. (deposition date: 2021-12-10, release date: 2023-06-14, Last modification date: 2023-07-12) |
Primary citation | Metwally, E.,Mak, V.,Sylvestre, H.L.,McEwan, P.,Baker, J.J.,Rose, Y.,Patel, A.,Lim, Y.-H.,Healy, D.,Hanisak, J.,Ermakov, G.,Beaumont, M.,Cheng, A.C.,Greshock, T.,Fischmann, T.O. Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023 |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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