7T2B

Crystal structure of the 5F TCR in complex with HLA-DP4-Ply

Summary for 7T2B

Entry DOI	10.2210/pdb7t2b/pdb
Descriptor	HLA class II histocompatibility antigen, DP alpha 1 chain, HLA class II histocompatibility antigen, DP beta 1 chain, Pneumolysin-derived peptide, ... (9 entities in total)
Functional Keywords	tcr-phla complex, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	20
Total formula weight	382319.20
Authors	Ciacchi, L.,Farenc, C.,Petersen, J.,Reid, H.H.,Rossjohn, J. (deposition date: 2021-12-03, release date: 2022-12-28, Last modification date: 2023-10-25)
Primary citation	Ciacchi, L.,van de Garde, M.D.B.,Ladell, K.,Farenc, C.,Poelen, M.C.M.,Miners, K.L.,Llerena, C.,Reid, H.H.,Petersen, J.,Price, D.A.,Rossjohn, J.,van Els, C.A.C.M. CD4 + T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity. Immunity, 56:1082-1097.e6, 2023 Cited by PubMed: 37100059 DOI: 10.1016/j.immuni.2023.03.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation