7T1D
Human SIRT2 in complex with small molecule 359
Summary for 7T1D
Entry DOI | 10.2210/pdb7t1d/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, SULFATE ION, ... (7 entities in total) |
Functional Keywords | allosteric inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 70219.69 |
Authors | Kulp, J.L.,Remiszewski, S.,Todd, M.,Chiang, L.W. (deposition date: 2021-12-01, release date: 2023-05-17, Last modification date: 2024-04-03) |
Primary citation | Roche, K.L.,Remiszewski, S.,Todd, M.J.,Kulp 3rd, J.L.,Tang, L.,Welsh, A.V.,Barry, A.P.,De, C.,Reiley, W.W.,Wahl, A.,Garcia, J.V.,Luftig, M.A.,Shenk, T.,Tonra, J.R.,Murphy, E.A.,Chiang, L.W. An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity. J.Clin.Invest., 133:-, 2023 Cited by PubMed: 37317966DOI: 10.1172/JCI158978 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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