7T17

Zika Virus asymmetric unit bound with IgM antibody DH1017 Fab fragment

Summary for 7T17

Entry DOI	10.2210/pdb7t17/pdb
EMDB information	25606
Descriptor	DH1017.IgM FabC constant domain, DH1017.IgM LambdaC constant domain, DH1017.IgM IgH, ... (5 entities in total)
Functional Keywords	zika virus particle, igm, fab fragment, neutralization, virus
Biological source	Homo sapiens (human) More
Total number of polymer chains	9
Total formula weight	199678.72
Authors	Miller, A.S.,Kuhn, R.J. (deposition date: 2021-12-01, release date: 2022-11-23, Last modification date: 2022-12-21)
Primary citation	Singh, T.,Hwang, K.K.,Miller, A.S.,Jones, R.L.,Lopez, C.A.,Dulson, S.J.,Giuberti, C.,Gladden, M.A.,Miller, I.,Webster, H.S.,Eudailey, J.A.,Luo, K.,Von Holle, T.,Edwards, R.J.,Valencia, S.,Burgomaster, K.E.,Zhang, S.,Mangold, J.F.,Tu, J.J.,Dennis, M.,Alam, S.M.,Premkumar, L.,Dietze, R.,Pierson, T.C.,Ooi, E.E.,Lazear, H.M.,Kuhn, R.J.,Permar, S.R.,Bonsignori, M. A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization. Cell, 185:4826-4840.e17, 2022 Cited by PubMed: 36402135 DOI: 10.1016/j.cell.2022.10.023 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.26 Å)

Structure validation