7SYF

Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)

Summary for 7SYF

• Entry DOI: 10.2210/pdb7syf/pdb
• EMDB information: 25524 25525 25526
• Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera (1 entity in total)
• Functional Keywords: guanine nucleotide exchange factor, metastasis, plasma membrane, rho gtpase signalling, oncoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 191462.98

Authors

Lupton, C.J.,Bayly-Jones, C.,Ellisdon, A.M. (deposition date: 2021-11-24, release date: 2022-07-27, Last modification date: 2024-02-28)

• Primary citation: Chang, Y.G.,Lupton, C.J.,Bayly-Jones, C.,Keen, A.C.,D'Andrea, L.,Lucato, C.M.,Steele, J.R.,Venugopal, H.,Schittenhelm, R.B.,Whisstock, J.C.,Halls, M.L.,Ellisdon, A.M.; Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.; Nat.Struct.Mol.Biol., 29:767-773, 2022; PubMed: 35864164; DOI: 10.1038/s41594-022-00804-9

Experimental method